Table 1– Definition of the phenotypes

	Definition	Study subjects n
Precapillary phenotype	Diagnosis of a precapillary disease^# AND	93
	No clinical diagnosis of CHF AND
	No moderate/severe mitral or aortic valve disease or replacement, systolic dysfunction^¶ or diastolic dysfunction⁺ on echocardiogram
Post-capillary phenotype	Clinical diagnosis of CHF OR moderate/severe mitral or aortic valve disease or replacement, systolic dysfunction^¶ or diastolic dysfunction⁺ on echocardiogram AND	134
	No diagnosis of precapillary disease^#
Mixed phenotype	Clinical diagnosis of CHF OR moderate/severe mitral or aortic valve disease or replacement, systolic dysfunction^¶ or diastolic dysfunction⁺ on echocardiogram AND	76
	Diagnosis of a precapillary disease^#

CHF: congestive heart failure. ^#: diagnosis of World Health Organization group 1 pulmonary hypertension, chronic thromboembolic pulmonary hypertension, obstructive lung disease or restrictive lung disease; ^¶: indicated by reduced ejection fraction (<50%) or wall motion abnormalities; ⁺: indicated by left ventricular hypertrophy or Doppler evidence of impaired relaxation.