Table 3– Cardiopulmonary exercise testing in nonhypoxaemic patients with symptomatic chronic hypersensitivity pneumonitis#
Non-PHPre-capillary PHp-value
Patients n1910
Peak WR W49 (38–55)45 (30–64)0.70
Metabolic responses
 Peak VO2 % predicted80±1368±200.06
 Peak VO2 mL·kg−1·min−115.0±2.512.8±1.60.02
VO2 at AT % VO2max predicted50±841±110.04
 ΔVO2/ΔWR mL·min−1·W−18.8±1.69.9±2.90.24
Cardiovascular responses
 Peak heart rate beats·min−1124±22121±140.72
 Peak heart rate % predicted77±1576±50.75
 Δheart rate/ΔVO2 beats·L−169±2762±240.27
 Peak VO2/heart rate % predicted97 (85–117)99 (62–110)0.51
 Peak SBP mmHg170 (160–170)155 (150–163)0.05
Ventilatory responses
VE/MVV0.61 (0.51–0.92)0.66 (0.60–0.86)0.65
VE/VCO2 at AT37±738±70.67
 Peak PETCO2 mmHg35±436±50.61
PETCO2 at AT mmHg37±438±50.79
 Peak SpO2 %93 (86–95)87 (84–90)0.06
Subjective responses
 Peak dyspnoea Borg score5±26±20.51
 Peak leg effort Borg score6±25±30.31
  • Data are presented as median (interquartile range) or mean±sd, unless otherwise stated. PH: pulmonary hypertension; WR: work rate; VO2: oxygen uptake; AT: anaerobic threshold; Δ: change in; SBP; systolic blood pressure; VE: minute ventilation; MVV: maximal voluntary ventilation; VCO2: carbon dioxide production; PETCO2: end-tidal carbon dioxide tension; SpO2: arterial oxygen saturation measured by pulse oximetry. #: n=29; : we were not able to determine the AT in eight patients (three from the pre-capillary PH group).