Table 1– Baseline characteristics of patients with symptomatic chronic hypersensitivity pneumonitis
TotalNon-PHPre-capillary PHp-value#
Patients502522
Females39 (78)21 (84)15 (68)0.18
Age years61±1161±1260±110.80
Body mass index kg·m−228±528±528±60.59
Baseline dyspnoea index6±26±25±20.07
NYHA functional class II/III/IV18/27/210/15/08/12/20.31
Pulmonary function testing
 FVC % predicted59±2269±2250±17<0.01
 FEV1 % predicted65±2475±2354±17<0.01
DLCO % predicted44±1547±1437±120.03
 FVC/DLCO % predicted1.5 (1.4–1.7)1.5 (1.3–1.7)1.6 (1.4–1.8)0.68
Blood gas analysis
PaO2 at rest mmHg68.5 (54.5–75.0)73.0 (62.2–78.5)59.0 (47.8–69.3)<0.01
PaCO2 at rest mmHg37.9±4.737.5±3.838.1±5.40.68
6-min walk test
 Distance m338±105365±99321±1080.15
 Final SpO2 %82±986±778±8<0.01
Echocardiography+
 TRV m·s−12.8±0.62.6±0.33.1±0.80.08
 sPAP mmHg35 (30–40)34 (30–36)38 (29–49)0.31
NT-proBNP pg·mL−178.7 (44.9–143.1)78.7 (49.7–128.4)68.8 (34.8–145.8)0.71
Right heart catheterisation
 RAP mmHg8±47±37±40.72
 mPAP mmHg25 (21–30)21 (20–23)30 (27–35)<0.01
 PAWP mmHg10±410±310±40.74
 TPG mmHg15 (11–19)11 (10–14)19 (17–25)<0.01
 PVR Wood units3.2 (2.3–3.8)2.3 (1.9–2.8)4.0 (3.5–4.9)<0.01
 Cardiac index L·min−1·m−22.8 (2.4–3.0)2.8 (2.4–3.2)2.7 (2.4–2.9)0.59
  • Data are presented as n, n (%), mean±sd or median (interquartile range), unless otherwise stated. PH: pulmonary hypertension; NYHA: New York Heart Association; FVC: forced vital capacity; FEV1: forced expiratory volume in 1 s; DLCO: diffusing capacity of the lung for carbon monoxide; PaO2: arterial oxygen tension; PaCO2: arterial carbon dioxide tension; SpO2: arterial oxygen saturation measured by pulse oximetry; TRV: tricuspid regurgitant jet velocity; sPAP: systolic pulmonary arterial pressure; NT-proBNP: N-terminal pro-brain natriuretic peptide; RAP: right atrial pressure; mPAP: mean pulmonary arterial pressure; PAWP: pulmonary arterial wedge pressure; TPG: transpulmonary gradient; PVR: pulmonary vascular resistance. #: comparing pre-capillary PH patients with non-PH patients. : FVC and FEV1 values could not be obtained in two patients (one from each group); DLCO values could not be obtained in nine patients (six from the pre-capillary PH group). +: 17 patients had no detectable tricuspid regurgitant jet (eight from the pre-capillary PH group).