Table 2– Haemodynamic, pulmonary functional and echocardiographic characteristics across different mean pulmonary arterial pressure (mPAP) ranges
mPAP ≤20 mmHgmPAP 21–24 mmHgmPAP 25–35 mmHgmPAP >35 mmHgp-value#
Patients n718175
PVR Wood units2.2±0.72.5±0.54.2±1.1*6.0±1.4*,§,ƒ<0.01
Cardiac index L·min−1·m−22.6±0.52.9±0.52.7±0.32.7±0.20.51
FVC % predicted65±1670±2452±17§38±14§0.01
PaO2 at rest mmHg75.9±8.368.8±11.961.6±11.2*45.4±9.4*,§,ƒ<0.01
6MWT final SpO2 %87±685±881±769±5*,§,ƒ<0.01
TRV+ m·s−12.5±0.32.7±0.32.7±0.53.8±0.8*,§,ƒ<0.01
sPAP on echocardiography+ mmHg33±333±634±1138±16*,§,ƒ<0.01
  • Data are presented as mean±sd unless otherwise stated. PVR: pulmonary vascular resistance; FVC: forced vital capacity; PaO2: arterial oxygen tension; 6MWT: 6-min walk test; SpO2: arterial oxygen saturation measured by pulse oximetry; TRV: tricuspid regurgitant jet velocity; sPAP: systolic pulmonary arterial pressure. #: intergroup comparison by ANOVA; : could not be obtained in two patients (one had an mPAP of 21–24 mmHg and one had mPAP >35 mmHg); +: 17 patients had no detectable tricuspid regurgitant jet (three had mPAP ≤20 mmHg, six had an mPAP of 21–24 mmHg, seven had an mPAP of 25–35 mmHg and one had mPAP >35 mmHg). *: p<0.05 compared with mPAP ≤20 mmHg; §: p<0.05 compared with an mPAP of 21–24 mmHg; ƒ: p<0.05 compared with an mPAP of 25–35 mmHg.