Least squares mean treatment difference
Day 1QVA149–PBOQVA149–INDQVA149–NVAQVA149–TIO
Trough FEV1 (mL)+190*80*80*80*
FEV1 AUC0–4h (mL)220*60*30*80*
Week 26
Trough FEV1 (mL)200*70*90*80*
FEV1 AUC0–4h (mL)340*110*140*130*
FEV1 AUC0–24h (mL)320*110*110*110*
Peak FEV1 (L)(0–4h)330*120*130*130*
Transition Dyspnea Index focal score1.09*0.260.210.51
St George's Respiratory Questionnaire total score–3.01–1.09–1.18–2.13
Rescue medication use–0.96*–0.30–0.66*–0.54*
  • +End of Day 1; *p<0.001; ‡p<0.01; †p<0.05