Table 4– Associations between exhaled nitric oxide fraction (FeNO), total NO2/NO3 and ratio levels in exhaled breath condensate (EBC) with allergic sensitisation
EBC NO2/NO3 level μmol per mg proteins#FeNO level ppb(NO2 + NO3)/NO ratio level+
nGM95% CIp-valuenGM95% CIp-valuenMean95% CIp-value
Allergic sensitisation
 No2192.031.73–2.3821912.611.6–13.62190.2911.6–13.6
 Yes3042.412.11–2.760.1030417.315.9–18.8<0.00013040.3115.9–18.80.7
Current rhinitis
 No3122.201.93–2.5131213.812.8–14.83120.300.25–0.36
 Yes2052.301.94–2.720.720517.716.1–19.6<0.00012050.290.22–0.360.8
SPT+ and current rhinitis
 No2192.031.73–2.3821912.611.6–13.62190.290.22–0.36
 SPT+1312.341.90–2.890.10§13115.914.0–18.0<0.0001§1310.290.21–0.380.6§
 Both1722.472.07–2.9417218.416.5–20.51720.320.25–0.39
Model adjusted for centre only
 Allergic sensitisation
  No2191.871.55–2.2621914.212.8–15.72190.250.17–0.33
  Yes3042.261.92–2.660.0630419.417.7–21.1<0.00013040.270.20–0.340.6
 Current rhinitis
  No3121.971.66–2.3331215.213.9–16.73120.250.18–0.32
  Yes2052.261.87–2.720.1920520.118.2–22.2<0.00012050.270.19–0.350.7
 SPT+ and current rhinitis
  No2191.871.55–2.2621914.212.8–15.72190.250.17–0.33
  SPT+1312.121.70–2.640.04§13117.515.6–19.8<0.0001§1310.240.15–0.340.4§
  Both1722.371.94–2.8917220.718.6–23.01720.290.20–0.37
Model adjusted for all covariates
Allergic sensitisation
  No2151.721.38–2.1421914.813.3–16.52190.210.13–0.30
  Yes2952.361.96–2.840.00830418.316.7–20.00.00063040.290.22–0.360.10
 Current rhinitis
  No3051.901.57–2.3131215.414.0–16.93120.240.16–0.31
  Yes1992.311.87–2.840.0920519.217.4–21.20.00012050.280.20–0.360.3
 SPT+ and current rhinitis
  No2151.711.37–2.1321914.813.3–16.52190.210.12–0.29
  SPT+1282.171.70–2.760.005§13116.414.6–18.4<0.0001§1310.260.17–0.360.06§
  Both1662.502.01–3.1217219.717.7–21.91720.320.23–0.40
 Allergic sensitisation (indoor only)
  No2151.661.28–2.1621914.212.7–15.92190.210.10–0.31
  Yes762.031.47–2.810.28017.114.8–19.70.02800.260.13–0.400.4
 Allergic sensitisation (outdoor only)
  No2151.661.28–2.1521914.613.2–16.32190.200.09–0.31
  Yes451.781.21–2.620.74617.214.6–20.20.06460.200.03–0.360.9
 Allergic sensitisation (moulds only)
  No2171.581.20–2.0621914.513.0–16.22190.180.07–0.30
  Yes73.961.69–9.290.04721.214.6–30.60.0670.490.11–0.870.12
  • GM: geometric mean; SPT+: positive skin prick test, i.e. a mean wheal diameter ≥3 mm than the negative control for at least one of 12 aeroallergens. #: adjusted for age, sex, smoking, ambient ozone concentration, asthma and centre; : adjusted for age, sex, smoking, height, asthma and centre (generalised estimating equation regression methods); +: adjusted for age, sex, smoking, asthma and centre; §: p-value for trend.