Table 3– Characteristics of all patients according to EGFR mutations
WildtypeEGFR mutatedp-value
Patients#96 (58.2)69 (41.8)
Age
 <60 years52 (54.2)33 (47.1)0.230
 >60 years44 (45.8)36 (52.9)
Sex
 Female53 (55.2)50 (72.5)0.018
 Male43 (44.8)19 (27.5)
ECOG
 0–169 (71.9)49 (72.1)0.562
 2–427 (28.1)20 (27.9)
Tumour stage
 III19 (19.8)10 (13.2)0.188
 IV77 (80.2)59 (86.8)
Smoking status
 Positive52 (54.2)17 (24.6)
 Negative44 (45.8)52 (75.4)<0.001
Wood smoke exposure
 Positive31 (32.3)43 (61.8)<0.001
 Negative65 (67.7)26 (38.2)
Histological subtypes
 Lepidic predominant4 (50.0)4 (50.0)0.665
 Acinar predominant35 (58.3)25 (41.7)
 Papillary predominant8 (50.0)8 (50.0)
 Micropapillary predominant
 Solid predominant
3 (75.0)
34 (66.7)
1 (25.0)
17 (33.3)
 NA12 (46.2)14 (53.8)
Groups
 Intermediate39 (57.4)29 (42.6)0.308
 High45 (63.4)26 (36.6)
 NA12 (46.2)14 (53.8)
  • Data are presented as n (%), unless otherwise stated. #: total number of patients was 145. EGFR: epidermal growth factor receptor; ECOG: Eastern Cooperative Oncology Group; NA: not applicable.