| CPAP | Zonisamide | p-value | |
| Subjects n | 11 | 22 | |
| Weight kg | 2.3 (1.0–3.6) | -2.7 (-4.1– -1.4) | <0.01 |
| BMI kg·m−2 | 0.7 (0.3–1.2) | -0.8 (-1.2– -0.4) | <0.01 |
| Waist/hip ratio | -0.007 (-0.021–0.008) | -0.003 (-0.015–0.010) | ns |
| Neck circumference cm | 0.2 (-0.4–0.7 ) | -1.3 (-1.7– -0.9) | <0.01 |
| Sagittal diameter cm | 0.4 (-0.8–1.5) | -1.9 (-3.0– -0.8) | 0.01 |
| Systolic BP mmHg | 1.1 (-10.5–12.8)# | -5.7 (-13.0–1.5) | ns |
| Diastolic BP mmHg | -7.2 (-14.4– -0.1)# | -4.0 (-6.9– -1.1) | ns |
| Heart rate beats·min−1 | 0.7 (-3.6–5.0)# | -2.1 (-4.3–0.1) | ns |
| AHI events·h−1 | -42.5 (-57.7– -27.3) | -8.0 (-15.9– -0.2) | <0.01 |
| ODI events·h−1 | -40.4 (-55.2– -25.5) | -8.1 (-15.1– -0.2) | <0.01 |
| Apnoea duration s | -4.3 (-10.3–1.7) | 5.9 (0.8–11.0) | 0.02 |
| Arousal index events·h−1 | -28.6 (-44.6– -12.7) | -5.1 (-13.3–3.2) | <0.01 |
| Mean SpO2 % | 2.8 (0.9–4.7) | 0.8 (0.2–1.4) | 0.01 |
| Minimum SpO2 % | 8.1 (5.1–11.2) | 2.4 (0.2–4.7) | <0.01 |
| T<90%sat % | -16.3 (-37.3–4.8) | -8.2 (-14.4– -2.1) | ns |
| TST h | 0.4 (-0.3–1.1) | -0.2 (-0.8–0.4) | ns |
| Sleep efficiency % | -2.6 (-8.8–3.6) | -3.9 (-8.1–0.3) | ns |
| Stage R % of TST | 5.4 (2.1–8.7) | -2.7 (-5.4–0.0) | <0.01 |
| Stage N3 % of TST | -1.4 (-5.0–2.3) | 0.1 (-3.1–3.4) | ns |
| ESS score | -4.4 (-7.0– -1.7) | -0.4 (-2.4–1.5) | 0.02 |
| FIS score | -19.0 (-29.2–8.8) | -3.6 (-12.8–5.5) | 0.04 |
| Zung depression score | -4.4 (-8.0– -0.8) | 2.8 (-1.0–6.6) | 0.02 |
| Zung anxiety score | -3.1 (-5.4– -0.8) | 0.7 (-2.1–3.4) | 0.07 |
| Bicarbonate mmol·L−1 | 0.7 (0.1–1.3) | -2.3 (-3.0– -1.6) | <0.01 |
| Creatinine μmol·L−1 | -0.6 (-5.5–4.2) | 7.1 (2.6–11.6) | 0.03 |
Data are presented as mean change (95% CI), unless otherwise stated. CPAP values are not corrected for compliance. BMI: body mass index; BP: blood pressure; AHI: apnoea/hypopnoea index; ODI: oxygen desaturation index; SpO2: arterial oxygen saturation measured by pulse oximetry; T<90%sat: time spent with SpO2 <90%; TST: total sleep time; ESS: Epworth Sleepiness Scale; FIS: Fatigue Impact Scale; ns: nonsignificant (p>0.1). #: n=9.