Table 2– Characteristics of the patients in the initial cohort in relation to their hospital of origin
Hospital 1Hospital 2Hospital 3Hospital 4Hospital 5Hospital 6Hospital 7ANOVA p-value
Subjects n1814131873998324
Age years70.6±8.957.6±13.254.4±18.9945.4±18.656.5±16.761.7±13.467.4±12.10.0001
Male85 (47)11 (27)146 (46)22 (30)45 (45.4)34 (41)14 (58)0.003
Aetiology0.0001
 Post-infection76 (42)11 (26.8)69 (21.7)23 (31.5)38 (38.4)30 (36.1)10 (41.7)
 Immunodeficiency5 (2.8)3 (7.3)77 (24.2)2 (2.7)8 (8.1)4 (4.8)1 (4.2)
 Other17 (9.4)11 (26.8)61 (19.2)22 (30.1)15 (15.2)21 (25.3)6 (25)
 Idiopathic83 (46)16 (39)111 (35)26 (36)38 (38)28 (34)7 (29)
Dyspnoea mMRC score2.06±11.73±11.22±1.211.22±1.370.94±0.91.28±1.11.46±0.90.0001
Mucopurulent or purulent sputum80 (44.2)25 (61.5)126 (39.6)35 (47.9)51 (51.2)44 (53)10 (41.7)0.0001
Respiratory insufficiency43 (24)2 (5)6 (2)5 (7)9 (9)11 (13)5 (21)0.0001
Lobes affected2.56±1.32.17±1.12.45±11.96±0.62.82±1.12.87±1.542.96±1.20.0001
Post-bronchodilator FEV1 % predicted60.2±21.570.8±26.576.3±26.667.5±22.162.3±26.671.5±26.254.9±20.50.0001
Chronic colonisation of Pseudomonas aeruginosa32 (18)15 (36)105 (33)41 (56)30 (30.3)21 (25)9 (38)0.0001
Hospitalisations in previous year0.29±0.70.76±10.98±1.50.41±0.70.73±1.40.66±11±1.250.0001
Death52 (29)6 (15)51 (16)6 (8)21 (21)12 (14)5 (21)0.002
  • Data are presented as mean±sd or n (%), unless otherwise stated. n=819. mMRC: Modified Medical Research Council; FEV1: forced expiratory volume in 1 s.