| Placebo | Zonisamide | p-value | |
| Subjects n | 15 | 13 | |
| Weight kg | 0.7 (-0.1–1.4) | -0.6 (-1.2–0.0) | <0.01 |
| BMI kg·m−2 | 0.2 (0.0–0.4) | -0.2 (-0.4–0.0) | <0.01 |
| Waist/hip ratio | 0.007 (-0.008–0.022) | -0.004 (-0.015–0.067) | ns |
| Neck circumference cm | -0.1 (-0.5–0.7) | -0.8 (-1.4– -0.1) | 0.06 |
| Sagittal diameter cm | -0.8 (-1.8–0.4) | -0.3 (-0.9–0.4) | ns |
| Systolic BP mmHg | -1.1 (-7.4–5.1) | -4.9 (-11.3–1.5) | ns |
| Diastolic BP mmHg | -2.8 (-5.6–0.0) | -0.5 (-5.0–4.0) | ns |
| Heart rate beats·min−1 | 0.5 (-3.5–4.6) | 0.5 (-4.3–3.2) | ns |
| ESS score | -0.3 (-2.3–1.6) | 1.4 (-0.6–3.4) | ns |
| FIS score | -2.3 (-11.4–6.9) | -0.2 (-6.9–6.5) | ns |
| Zung depression score | -1.9 (-4.5–0.8) | 2.6 (-0.6–5.7) | 0.03 |
| Zung anxiety score | -1.9 (-5.5–1.7) | 2.0 (-2.0–6.0) | ns |
| Bicarbonate mmol·L−1 | 0.3 (-0.2–0.8) | -2.7 (-3.5– -1.9) | <0.01 |
| Creatinine μmol·L−1 | -6.3 (-13.5–0.9) | 8.1 (5.0–11.3) | <0.01 |
Data are presented as mean change (95% CI), unless otherwise stated. BMI: body mass index; BP: blood pressure; ESS: Epworth Sleepiness Scale; FIS: Fatigue Impact Scale; ns: nonsignificant (p>0.1).