Table 2– Functional class, 6-min walk distance (6MWD) and haemodynamics at the baseline, month 4 and final follow-up visits

	Baseline	Month 4 visit	Final follow-up visit^#
NYHA FC I/II/III/IV n	0/0/8/10	1/16/1/0**	4/14/0/0**
6MWD m	227±171	463±94**	514±105**^,¶
Haemodynamics
RAP mmHg	11.9±5.2	4.9±4.9**	5.2±3.5**
mPAP mmHg	65.8±13.7	45.7±14.0**	44.4±13.4**
PCWP mmHg	8.4±3.5	6.7±3.2	7.9±2.8
Cardiac index L·min⁻¹·m⁻²	1.66±0.35	3.49±0.69**	3.64±0.65**
PVR dyn·s·cm⁻⁵	1718±627	564±260**	492±209**
Mean BP mmHg	92.1±12.5	80.1±11.7**	84.9±19.4
HR beats per min	92.3±10.7	83.9±9.8**	79.9±13.4**
S_vO₂ %	51.0±8.5	69.7±5.2**	72.2±4.0**
Dose of epoprostenol achieved ng·kg⁻¹·min⁻¹	0	15.9±1.9	19.6±6.0

Data are presented as mean±sd unless otherwise stated. n=18. NYHA: New York Heart Association; FC: functional class; 6MWD: 6-minute walk distance; RAP: right atrial pressure; mPAP: mean pulmonary arterial pressure; PCWP: pulmonary capillary wedge pressure; PVR: pulmonary vascular resistance; BP: blood pressure; HR: heart rate; S_vO₂: mixed venous oxygen saturation. ^#: follow-up time 32±19 months. **: p<0.01 versus baseline; ^¶: p<0.01 versus month 4 visit.