Table 2– Exacerbation frequency classified by severity of airflow limitation
All subjectsGOLD 1GOLD 2GOLD 3GOLD 4
Subjects268691216513
Exacerbation events per person per year
 Subjective complaint0.78±1.160.58±0.790.63±0.941.09±1.51*,#1.80±1.86*,#
 Symptom definition0.24±0.470.16±0.290.16±0.270.37±0.57*,#0.81±1.15*,#
 Prescription definition0.20±0.430.12±0.260.14±0.250.30±0.49*,#0.77±1.13*,#,¶
 Antibiotics definition0.13±0.280.09±0.230.09±0.220.20±0.35*,#0.37±0.42*,#,¶
 Admission definition0.06±0.190.01±0.030.06±0.19*0.10±0.27*,#0.09±0.15*
  • Data are presented as n or mean±sd. GOLD: Global Initiative for Chronic Obstructive Lung Disease. *: p<0.05 versus GOLD 1; #: p<0.05 versus GOLD 2; : p<0.05 versus GOLD 3.