Table 1– Characteristics of subjects classified by severity of airflow limitation
All subjectsGOLD 1GOLD 2GOLD 3GOLD 4
Subjects n268691216513
Age years70±867±870±872±670±8
Females15 (6)9 (13)6 (5)0 (0)0 (0)
Body mass index kg·m−222±323±323±321±321±4
Current smoker at entry74 (28)20 (29)39 (32)10 (15)5 (38)
Smoking index at entry pack-years62±3063±3462±3064±2555±22
Post-bronchodilator
 FEV1 L1.75±0.672.55±0.431.76±0.411.11±0.190.70±0.14
 FEV1 % predicted65±2293±1165±942±526±4
 FVC % predicted101±19118±13100±1490±1470±20
 FEV1/FVC0.51±0.130.64±0.060.53±0.080.38±0.070.31±0.07
Reversibility of FEV1 %12±106±512±817±1314±11
Reversibility of FEV1 mL146±105124±88162±101153±12786±66
Chronic bronchitis29 (11)2 (3)15 (12)11 (17)1 (8)
MRC dyspnoea score ≥2224 (84)47 (68)102 (84)62 (95)13 (100)
SGRQ total score32±1823±1430±1741±1651±14
Blood neutrophil count cells·mm−33519±11133597±12203421±11553580±9753713±733
Blood eosinophil count cells·mm−3198±134185±130211±137184±128218±152
Blood haemoglobin g·dL−114±114±114±114±114±1
Serum IgE IU·mL−1213±569278±764251±60688±106140±158
Any cardiovascular disease60 (22)12 (17)27 (22)17 (26)4 (31)
Ischaemic heart disease19 (7)5 (7)9 (7)5 (8)0 (0)
Diabetes12 (4)3 (4)7 (6)2 (3)0 (0)
  • Data are presented as mean±sd or n (%), unless otherwise stated. GOLD: Global Initiative for Chronic Obstructive Lung Disease; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; MRC: Medical Research Council; SGRQ: St George’s Respiratory Questionnaire.