Table 1– Characteristics of the study subjects#
Age years67±10
Males49 (45)
Race
 Caucasian87 (80)
 Asian17 (16)
 Unknown5
Smoking history
 Current smokers17 (16)
 Former smokers92 (84)
 Pack-years46±25
Spirometry
 FEV1 % pred pre-bronchodilator (n=109)83±20
 FEV1 % pred post-bronchodilator (n=97)87±19
 FVC % pred pre-bronchodilator (n=109)92±17
 FVC % pred post-bronchodilator (n=97)95±16
 FEV1/FVC % pre-bronchodilator (n=109)70±11
 FEV1/FVC % post-bronchodilator (n=100)70±13
DLCO/VA % pred (n=81)75±20
 RV/TLC % (n=73)44±10
GOLD classification
 064
 119
 220
 35
 41
α1-antitrypsin genotype
 MM104 (97)
 MZ3 (3)
 ZZ0 (0)
  • Data are presented as mean±sd, n (%) or n. FEV1: forced expiratory volume in 1 s; % pred: % predicted; FVC: forced vital capacity; DLCO: diffusing capacity of the lung for carbon monoxide; VA: alveolar volume; RV: residual volume; TLC: total lung capacity; GOLD: Global Initiative for Chronic Obstructive Lung Disease. #: n=109; : two subjects were not genotyped because genomic DNA could not be obtained.