Table 2– Differences in the estimated marginal means of forced expiratory volume in 1 s (FEV1) % predicted computed from the linear regression models; representing the estimated effect of each factor on FEV1
Adjustment for age and countryAdjustment for age, country and all other factors
Differencep-valueDifferencep-value
Genotype#<0.00010.0005
 Severe/severe – severe/mild-10.9 (-12.6− -9.1)-3.8 (-5.9− -1.6)
 Severe/severe – mild/mild-7.1 (-15.7–1.6)0.7 (-10.5–12.0)
 Severe/severe – unclassified-5.7 (-6.5− -4.8)-2.8 (-3.9− -1.7)
 Severe/mild – mild/mild3.8 (-5.0–12.6)4.5 (-6.8–15.9)
 Severe/mild – unclassified5.2 (3.4–7.0)1.0 (-1.1–3.1)
 Mild/mild – unclassified1.4 (-7.2–10.0)-3.5 (-14.8–7.7)
Sex
 Male – female1.1 (0.3–1.8)0.00512.7 (1.8–3.6)<0.0001
Pancreatic status
 Sufficient – insufficient12.9 (11.8–14.2)<0.00016.7 (5.2–8.2)<0.0001
CFRD
 Yes – no-11.6 (-12.8− -10.4)<0.0001-8.0 (-9.5− -6.6)<0.0001
Pseudomonas aeruginosa infection
 Yes – no-15.7 (-16.6− -14.7)<0.0001-13.0 (-14.0− -12.0)<0.0001
BMI<0.0001<0.0001
 Normal – poor23.1 (21.8–24.3)21.6 (20.0–23.2)
 Above normal – poor38.5 (32.8–44.1)29.1 (21.9–36.2)
 Above normal – normal15.4 (9.9–21.0)7.4 (0.5–14.4)
  • Data are presented as mean (95% CI), unless otherwise stated. CFRD: cystic fibrosis-related diabetes; BMI: body mass index. #: alleles classified according to McKone et al. [11]: severe (alleles that belong to either class I, II or III), mild (alleles that belong either to class IV or V) and unclassified (alleles that could not be classified into any of the previous classes); : normal: -2–2 standard deviation scores (SDS); poor: ≤ -2 SDS; above normal: >2 SDS.