Table 3– Per-patient analysis of the probe-based confocal laser endomicroscopy (pCLE) cellular features

pCLE features	A1: HP-AMR-IP^#	A2: LP-AMR-IP^¶	B: ILD without amiodarone therapy⁺	p-value	Diagnostic accuracy of pCLE features for HP-AMR-IP^§ (95% CI)
					Sensitivity	Specificity	PPV	NPV
Patients showing alveolar cellular infiltration	9	6	6	A1 versus A2=0.50 A1 versus B=0.008^## A2 versus B=0.29	1 (0.66–1)	0.25 (0.03–0.65)	0.60 (0.32–0.84)	1 (0.16–1)
Patients with alveolar cells ≥20 μm^ƒ	9	1	1	A1 versus A2=0.005^## A1 versus B=0.005^## A2 versus B=1	1 (0.66–1)	0.83 (0.36–1)	0.9 (0.55–1)	1 (0.48–1)
Patients with alveolar cells ≥30 μm^ƒ	8	1	0	A1 versus A2=0.03^## A1 versus B=0.004^## A2 versus B=1	0.89 (0.52–1)	0.83 (0.36–1)	0.89 (0.52–1)	0.83 (0.36–1)
Patients with alveolar areas where the cells appeared aggregated^ƒ	7	2	1	A1 versus A2=0.35 A1 versus B=0.11 A2 versus B=1	0.78 (0.4–0.97)	0.67 (0.22–0.96)	0.78 (0.4–0.97)	0.67 (0.22–0.96)
Fluorescence intensity of alveolar cells^ƒ	347±174	202±158	114±44	A1 versus A2=0.37 A1 versus B=0.02^## A2 versus B=0.77	NA	NA	NA	NA
Patients with alveolar cells >20 μm and fluorescence intensity >100 AU	9	1	1	A1 versus A2=0.001^## A1 versus B<0.001^## A2 versus B=1	1 (0.66–1)	0.88 (0.47–1)	0.9 (0.55–1)	1 (0.59–1)

Data are presented as n or mean±sd, unless otherwise stated. HP-AMR-IP: high probability of amiodarone-related interstitial pneumonia; LP-AMR-IP: low probability of amiodarone-related interstitial pneumonia; ILD: interstitial lung disease; PPV: positive predictive value; NPV: negative predictive value; NA: not applicable. ^#: n=9; ^¶: n=8; ⁺: n=16; ^§: group A1, control group is A2; ^ƒ: cellular characteristics are quantified from patients with at least one area showing cellular infiltration; ^##: significant values by Fisher’s exact test, the p-values presented here are corrected (Bonferroni).