Table 2– Pharmacokinetic parameters of linezolid and clarithromycin
Linezolidp-valueLinezolid + 500 mg clarithromycinp-value#
+ 0 mg clarithromycin+ 250 mg clarithromycin
Linezolid
 AUC0–12 mg·h·L−136.3 (33.2–46.3)61.0 (34.6–63.9)0.68667.2 (66.9–76.0)0.043
 Cmax mg·L−16.0 (5.1–6.4)8.0 (5.5–10.9)0.1049.4 (8.9–10.5)0.043
 Cmin mg·L−11.2 (0.9–1.6)2.1 (0.9–2.2)0.6862.6 (2.4–3.9)0.080
 Clearance L·h−17.0 (5.4–8.0)4.0 (3.5–7.8)0.6863.5 (2.7–3.5)0.080
 k h−10.17 (0.17–0.19)0.14 (0.12–0.18)0.7850.13 (0.11–0.13)0.080
 t1/2 h4.1 (3.6–4.2)4.9 (3.8–5.7)0.6865.4 (5.4–6.5)0.138
Clarithromycin
 AUC0–12 mg·h·L−1N/A8.2 (5.8–9.8)N/A20.1 (14.0–23.6)0.043
  • Data are presented as median (interquartile range). n=5. AUC0–12: area under the concentration–time curve from 0 to 12 h; Cmax: maximal serum concentration; Cmin: the concentration before intake of medication; k: elimination constant. N/A: not applicable. #: p-values comparing parameters from co-administration of linezolid with 500 mg clarithromycin to baseline; : p-value comparing AUC0–12 of 500 mg with 250 mg clarithromycin.