Mortality | ||

Patients alive at 2 years | Patients dead at 2 years | |

STS test number of repetitions in 1 min | 19.5±8.7 | 11.8±6.3 |

Association of STS with mortality | Unadjusted association (hazard ratio per 1 more repetition) | 0.86 (95% CI 0.81–0.92), p<0.0001; z= -4.73 |

Adjusted association (hazard ratio per 1 more repetition) | 0.90 (95% CI 0.83–0.97), p=0.004; z= -2.84 | |

Adjusted association (hazard ratio per 5 more repetitions) | 0.58 (95% CI 0.40–0.85) p=0.004; z= -2.84 | |

Covariates | Age 1.08 (se 0.026, z=3.17, p=0.002); FEV_{1} 0.98 (se 0.012, z= -1.76, p=0.078); dyspnoea 1.12 (se 0.185, z=0.69, p=0.49); LABA/ICS 0.56 (se 0.29, z= -1.11, p=0.269) | |

Exacerbations | ||

Patients with no exacerbation during 2 years of follow-up | Patients with ≥1 exacerbation during 2 years of follow-up | |

STS test number of repetitions in 1 min | 19.4±8.5 | 18.1±8.1 |

Association of STS test with exacerbations | Unadjusted association (incidence rate ratio per 1 more repetition) | 0.99 (95% CI 0.97–1.01), p=0.21; z= -1.26 |

Adjusted association (incidence rate ratio per 1 more repetition) | 1.00 (95% CI 0.98–1.02), p=0.94; z=0.08 | |

Covariates | Age 1.00 (se 0.007, z= -0.48, p=0.63); FEV_{1} 0.98 (se 0.005, z= -5.02, p<0.001); dyspnoea 1.06 (se 0.067, z=0.89, p=0.38); LABA/ICS 1.52 (se 0.34, z=1.87, p=0.062) | |

HRQoL from baseline to 2-year follow-up | ||

Association of STS test with CRQ dyspnoea | Unadjusted difference on scale from 1–7 per 1 more repetition | 0.06 (95% CI 0.04–0.07), p<0.001; z=7.55 |

Adjusted difference on scale from 1–7 per 1 more repetition | 0.05 (95% CI 0.04–0.07), p<0.001; z=7.10 | |

Adjusted difference on scale from 1–7 per 5 more repetitions | 0.26 (95% CI 0.19–0.34), p<0.001; z=7.10 | |

Covariates | Age 0.017 (se 0.007, z=2.54, p=0.011); FEV_{1} 0.026 (se 0.004, z= -6.48, p<0.001); LABA/ICS -0.396 (se 0.16, z=–2.41, p=0.016) | |

Association of STS test with CRQ fatigue | Unadjusted difference on scale from 1–7 per 1 more repetition | 0.06 (95% CI 0.04–0.07), p<0.001; z=8.57 |

Adjusted difference on scale from 1–7 per 1 more repetition | 0.04 (95% CI 0.03–0.05), p<0.001; z=6.06 | |

Adjusted difference on scale from 1–7 per 5 more repetitions | 0.19 (95% CI 0.13–0.26), p<0.001; z=6.06 | |

Covariates | Age 0.007 (se 0.005, z=1.34, p=0.18); FEV_{1} -0.007 (se 0.005, z= -2.04, p=0.042); dyspnoea 0.361 (se 0.038, z=9.51, p<0.001); LABA/ICS 0.108 (se 0.13, z=0.81, p=0.42) | |

Association of STS test with CRQ emotional function | Unadjusted difference on scale from 1–7 per 1 more repetition | 0.03 (95% CI 0.02–0.05), p<0.001; z=5.33 |

Adjusted difference on scale from 1–7 per 1 more repetition | 0.02 (95% CI 0.01–0.03), p=0.001; z=3.24 | |

Adjusted difference on scale from 1–7 per 5 more repetitions | 0.10 (95% CI 0.04–0.16), p=0.001; z=3.24 | |

Covariates | Age 0.013 (se 0.005, z=2.52, p=0.012); FEV_{1} -0.009 (se 0.003, z= -2.81, p=0.005); dyspnoea 0.357 (se 0.036, z=9.87, p<0.001); LABA/ICS 0.169 (se 0.13, z=1.32, p=0.19) | |

Association of STS test with CRQ mastery | Unadjusted difference on scale from 1–7 per 1 more repetition | 0.03 (95% CI 0.02–0.04), p<0.001; z=5.79 |

Adjusted difference on scale from 1–7 per 1 more repetition | 0.02 (95% CI 0.00–0.03), p=0.005; z=2.84 | |

Adjusted difference on scale from 1–7 per 5 more repetitions | 0.08 (95% CI 0.02–0.13), p=0.005; z=2.84 | |

Covariates | Age 0.008 (se 0.005, z=1.69, p=0.09); FEV_{1} -0.002 (se 0.003, z= -0.65, p=0.51); dyspnoea 0.340 (se 0.033, z=10.41, p<0.001); LABA/ICS -0.053 (se 0.116, z= -0.46, p=0.64) |

Data are presented as mean±sd, unless otherwise stated. FEV

_{1}: forced expiratory volume in 1 s; LABA: long-acting β-agonist; ICS: inhaled corticosteroid; CRQ; Chronic Respiratory Questionnaire. z-values are reported to show the relative strength of association of each variable in the multivariable regression models. All regression coefficients for continuous variables except for handgrip strength are per increase of 1 unit (1 year for age, 1% predicted for FEV_{1}and 1 point for dyspnoea).