Table 2– Sensitivity, specificity, positive predictive values (PPVs), and negative predictive values (NPVs) of the different parameters used for ciliary activity evaluation in suspension cell culture for the diagnosis of primary ciliary dyskinesia
Suspension cell cultures parametersSensitivity %Specificity %PPV %NPV %
Rotation of the spheroids97.279.067.398.5
Migration of the spheroids10017.334.9100
Ability of cilia to remove debris1007.432.4100
Normal ciliary beat pattern10064.255.4100
Pathological ciliary beat pattern33.310010077.1