| CA versus controls | SA versus CA | SA versus controls | Genes | Adjusted p-value# | |
| KEGG pathway | |||||
| Taste transduction (bitter) | - | ITPR3 | 0.03 | ||
| + | + | TAS2R45 | |||
| + + | + + | TAS2R13, TAS2R14, TAS2R19, TAS2R20, TAS2R31, TAS2R50 | |||
| + | TAS2R4, TAS2R46, TAS2R5 | ||||
| Natural killer cell-mediated cytotoxicity | + + + | CD244, CD247, FYN, SH2D1B, GZMB, ICAM2, KIR2DL1/KIR2DL2, KLRD1, NCR1, NFATC2 | 0.02 | ||
| + | - | HCST, NCR3, PRF1, ZAP70 | |||
| - | ITGAL, LAT | ||||
| - | - | TNFRSF10D | |||
| - | VAV2 | ||||
| N-glycan biosynthesis | - | - | B4GALT3, ALG3, DPAGT1 | 0.02 | |
| - - | ALG1, ALG12, ALG9, DPM2, GANAB, MOGS, RPN2 | ||||
| Dendogram row cluster¶ | |||||
| Natural killer cell-mediated cytotoxicity | A | CD244, CD247, FYN, SH2D1B, GZMB, HCST, ITGAL, ICAM2, KIR2DL1, LAT, NFATC2, PRF1, ZAP70 | 0.02 | ||
| T-cell receptor signalling pathway | A | CD247, CD4, CBLB, FYN, CARD11, LAT, NFATC2, NFKB1, PRKCQ, AKT2, ZAP70 | 0.03 | ||
| Citrate cycle (TCA cycle) | A | ACLY, ACO2, IDH2, IDH3A, IDH3B, MDH2 | 0.04 | ||
| NA | B | NA | |||
| NA | C | NA | |||
| Taste transduction (bitter) | D | TAS2R13, TAS2R14, TAS2R19, TAS2R20, TAS2R31, TAS2R4, TAS2R45, TAS2R46, TAS2R5, TAS2R50 | 4.2x10−10 | ||
+ or − indicates if the genes are significantly up- or downregulated, respectively, in each contrast. CA: controlled asthma; SA: severe asthma; KEGG: Kyoto Encyclopaedia of Genes and Genomes; TCA: tricarboxylic acid; NA: no significant pathways. #: Benjamini–Hochberg correction for multiple testing. ¶: see figure 2 for dendogram row cluster classification.