Infection | Subjects | Dosage regimen | t½ h | VD L·kg−1 | Clearance mL·min−1·kg−1 | AUC mg·L−1·h−1 | [Ref.] |
Bacterial skin disease | 12 | Single dose 0.23 g orally | 10.0±1.1 | N/A | N/A | 1295±823 | [6] |
Normal meninges | 9 | 25 mg·kg−1 over 120 min i.v. | 9.8±1.5 | 0.30±0.04 | 0.36±0.03 | 1160±103 | [7] |
AIDS | 8 | 75 mg·kg−1 daily i.v. | 15.5±7.4 | 0.5±0.3 | 0.40±0.12 | N/A | [8] |
HIV | 10 | 800 mg once daily orally | N/A | N/A | N/A | 574.2 (342.6–796.3) | [9] |
Data are presented as n, mean±sd or median (range). t½: half-life; VD: volume of distribution; AUC: area under the concentration–time curve; N/A: not available.