| First author [Ref.] | Trial acronym | Year | Baseline PVR dyn·s−1·cm−5 | ΔPVR | Baseline PAP mmHg | ΔPAP | Baseline cardiac index L·min−1·m−2 | ΔCI | Baseline Pra mmHg | ΔPra |
| Badesch [9] | 2000 | 1017 | -43.3 | 50 | -11.9 | 2.0 | 29.3 | 12 | -20.3 | |
| Barst [10] | PPHSG | 1996 | 1280 | -30.6 | 60 | -11.2 | 2.0 | 24.4 | 13 | -18.4 |
| Barst [11] | 2003 | NA | NA | 56 | -1.8 | 2.5 | NA | 9 | -11.7 | |
| Barst [12] | STRIDE-1 | 2004 | 966 | -27.9 | 53 | -5.7 | 2.4 | 12.5 | 8 | -13.3 |
| 929 | -26.1 | 53 | -9.4 | 2.3 | 17.0 | 9 | -23.5 | |||
| Galiè [13] | ALPHABET | 2002 | NA | NA | 59 | -3.4 | 2.4 | 8.3 | 8 | -11.8 |
| Galiè [14] | SUPER | 2005 | 1019 | -16.8 | 55 | -4.9 | 2.3 | 10.0 | 8 | -12.9 |
| 962 | -20.0 | 53 | -6.1 | 2.2 | 11.6 | 9 | -15.5 | |||
| 984 | -31.5 | 54 | -9.8 | 2.3 | 16.6 | 9 | -14.4 | |||
| Galiè [4] | EARLY | 2008 | 822 | -20.3 | 52 | -10.9 | 2.7 | 8.9 | 7 | -8.3 |
| Ghofrani [15] | 2010 | 1121 | -26.1 | 60 | -9.9 | NA | NA | NA | NA | |
| Humbert [5] | BREATHE-2 | 2004 | 1483 | -12.7 | 60 | -6.7 | 1.7 | 11.8 | 12 | -18.5 |
| Jing [16] | EVALUATION | 2011 | 1255 | -30.0 | 61 | -8.8 | 2.3 | 17.4 | 9 | -22.3 |
| McLaughlin [6] | STEP | 2006 | 802 | -30.5 | 51 | -15.5 | NA | NA | NA | NA |
| Olschewski [17] | AIR | 2002 | 1035 | -32.4 | 53 | -8.2 | NA | NA | NA | NA |
| Oudiz [7] | 2004 | NA | NA | 54 | -3.7 | 2.1 | 14.3 | 11 | -26.2 | |
| Rubin [8] | CIPPPH | 1990 | 1686 | -35.6 | 61 | 3.6 | 3.4 | NA | NA | NA |
| Simonneau [18] | 2002 | 2040 | -16.5 | 61 | -4.9 | 2.3 | 7.7 | 10 | -19.0 | |
| Simonneau [19] | PACES | 2008 | 806 | -24.8 | 52 | -7.55 | NA | NA | NA | NA |
Data are presented as % unless otherwise stated. PVR: pulmonary vascular resistance; ΔPVR: change in PVR; PAP: pulmonary arterial pressure; ΔPAP: change in PAP; Pra: right atrial pressure; ΔPra: change in Pra; NA: not available.