Table 2– Baseline characteristics of the study cohort
TotalChildrenAdolescents
Subjects724032
Male35 (48.6)20 (50)15 (46.9)
Age years13.4 (6–20)11.5 (6–14)16.5 (14–20)
FEV1 % predicted83.4 (22–110)85.7 (31–110)75.9 (22–110)
FVC % predicted91.9 (32–119)97.9 (53–119)85.9 (32–112)
FEF75 % predicted48.5 (6–95)48 (7–95)49.2 (6–92)
Positive Pseudomonas aeruginosa culture#26 (36)10 (25)16 (50)
Chronic infection with Pseudomonas aeruginosa 19 (26)5 (13)14 (44)
CF-CT total score %7.8 (0–33)5.2 (0–20)11.8 (0–33)
Bronchiectasis score %0.0 (0–26)0 (0–19)2.6 (0–26)
Airway wall thickening score %8.3 (0–37)4.9 (0–33)14.8 (0–37)
Mucus plugging score %8.3 (0–50)5.6 (0–50)16.7 (0–42)
Opacities %5.6 (0–19)4.6 (0–13)7.4 (0–19)
Trapped air %36.7 (0–97)33.3 (0–70)43.3 (7–97)
  • Data are presented as n, n (%) or median (range). FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; FEF75: forced expiratory flow at 75% of FVC; CF-CT: cystic fibrosis computed tomography scoring system. #: includes all positive Pseudomonas aeruginosa cultures positive in the year prior to computed tomography and Cystic Fibrosis Questionnaire-revised; : chronic infection with P. aeruginosa defined as three or more consecutive positive respiratory cultures for P. aeruginosa.