Table 4– Multivariate predictors of mortality and disease progression in unclassifiable interstitial lung disease (ILD)
VariableMortalityDisease progression#
HR (95% CI)p-valueOR (95% CI)p-value
DLCO % predicted0.59 (0.43–0.80)0.0010.67 (0.46–0.96)0.03
HRCT fibrosis score1.60 (1.08–2.37)0.022.29 (1.26–4.15)0.006
  • Hazard ratios (HR) and odds ratios (OR) are from stepwise regression, using a p-value of 0.05 for inclusion. Diffusing capacity of the lung for carbon monoxide (DLCO) and high-resolution computed tomography (HRCT) fibrosis scores were the only variables retained in the multivariate model. #: disease progression was defined as any of the following within 12 months of the initial visit to the University of California San Francisco ILD Clinic: 10% decline in forced vital capacity, 15% decline in DLCO, lung transplantation, or death due to any cause (this was only assessable in a subgroup of patients with complete follow-up data: n = 61); : HR reported for 10-unit change.