Table 4– Univariate and multivariate associations with pulmonary exacerbations in the year following computed tomography and completion of the Cystic Fibrosis Questionnaire-revised (CFQ-R)

Predictor	Univariate associations		Multivariate prediction model^#
Predictor	Rate ratio^¶ (95% CI)	p-value	Rate ratio^¶ (95% CI)	p-value
CF-CT bronchiectasis score	1.10 (1.02–1.19)	0.009		ns
CF-CT trapped air score	1.02 (1.00–1.05)	0.034		ns
CFQ-R RSS	0.95 (0.91–0.98)	0.002	0.96 (0.94–0.97)	<0.001
*Positive culture Pseudomonas aeruginosa* ⁺**	1.98 (1.22–3.23)	0.006	1.72 (1.10–2.69)	0.008
Age	1.21 (1.02–1.44)	0.030	1.52 (1.00–2.30)	0.001
Sex	1.03 (0.38–2.80)	0.951		ns

Data are presented as rate ratio (95% CI), unless otherwise stated. n = 72. In young children (6–13 years) the CFQ-R Child version was used. CF-CT: cystic fibrosis computed tomography; CFQ-R RSS: revised Cystic Fibrosis Questionnaire respiratory symptoms scale; ns: not significant. ^#: only variables significant at the p = 0.05 level are included in the multivariable model; ^¶: rate ratio for scores calculated per point increase in score; ⁺: defined as at least one positive respiratory culture for P. aeruginosa in the year before computed tomography and completion of CFQ-R.