Table 3– Previously identified asthma candidate genes enriched in our list of 1378 differentially expressed genes
IDGeneCA–controlSA–CASA–controlGene ontology function+
FCAdjusted p-value#FCAdjusted p-value#FCAdjusted p-value#Adjusted F-value, p-value#,¶
8043791INPP4A1.160.006-1.060.261.090.100.004Phosphatidylinositol 3,4-bisphosphate, 4,5-bisphosphate or 4-phosphatase activity; hydrolase activity
7921571PEX19-1.000.99-1.170.01-1.170.010.005Protein binding
7989365RORA1.260.02-1.030.781.220.020.006DNA, protein and zinc ion binding; transcription factor activity; steroid hormone receptor
8112220PDE4D1.280.01-1.090.401.180.080.007Catalytic and hydrolase activity; metal ion binding; 3',5'-cyclic-nucleotide phosphodiesterase activity
8075886IL2RB1.580.02-1.290.151.220.350.01Interleukin-2 receptor activity
8008029TBX211.360.03-1.230.111.110.560.02DNA binding; transcription factor activity
8122202MYB-1.080.62-1.110.17-1.200.010.03DNA replication and transcriptional repression
8014916ORMDL31.160.10-1.160.0541.010.970.04Protein binding
7913883PAFAH21.250.047-1.130.241.110.440.041-alkyl-2-acetylglycerophosphocholine esterase activity; hydrolase activity
8109086ADRB21.220.052-1.090.381.120.290.04β2-adrenergic receptor activity; protein binding
7974363PTGDR1.640.057-1.230.411.340.280.04Prostaglandin receptor activity; protein binding; signal transducer
8115455HAVCR11.160.18-1.180.050-1.010.930.048Receptor activity
  • CA: controlled asthma; SA: severe asthma; FC: fold change. #: Benjamini–Hochberg correction for multiple testing; : a global F-test to test for significance in any of the contrasts; +: a summary of gene ontology function from the European Bioinformatics Institute database quickGO.