| Lung tissue (PCR and IHC) | Sputum cells (ICC) | In vitro cell culture | |||||||
| COPD | Smokers | Nonsmokers | COPD | Smokers | Nonsmokers | CD8 COPD | Epithelial COPD | Neutrophils# COPD | |
| Subjects | 31 | 19 | 21 | 8 | 6 | 4 | 3 | 3 | 7 |
| Male/female | 17/14 | 8/11 | 8/13 | 5/3 | 0/6 | 3/1 | 2/1 | 3/0 | 4/3 |
| Age years | 66.4±7.2 | 61.5±13.1 | 59±15.6 | 72.5±4.4 | 52.3±6.8 | 54±14.7 | 63±3.6 | 60±6.9 | 74.1±3.1 |
| Smoking history pack-years | 50.9±25.6 | 44.3±29.4 | 0 | 52±8.9 | 29.8±8.6 | 0 | 61.3±38.7 | 21±1.3 | 47.6±6.9 |
| FEV1 L | 1.8±0.5 | 2.3±0.73 | 2.2±0.8 | 1.0±0.3 | 2.8±0.6 | 3.2±1.2 | 1.6±0.2 | 1.8±0.4 | 1.1±0.3 |
| FEV1 % pred | 66.7±11.6 | 91.3±16.7 | 93.6±19 | 43.6±10.8 | 101.0±9.1 | 106.4±9.6 | 59.7±14.6 | 53.5±6.2 | 47.0±15.7 |
| FEV1/FVC % | 57.2±8.6 | 73.8±7.2 | 75.7±10.5 | 42.0±10.3 | 76.2±4.2 | 75.0±3.6 | 52±12.2 | 50±8.7 | 46.7±8.7 |
| Subjects taking ICSs | 31 | 0 | 0 | 6 | 0 | 0 | 3 | 3 | 7 |
Data are presented as n or mean±sd. IHC: immunohistochemistry; ICC: immunocytochemistry; COPD: chronic obstructive pulmonary disease; FEV1: forced expiratory volume in 1 s; % pred: % predicted; FVC: forced vital capacity; ICS: inhaled corticosteroid. #: neutrophils were isolated from both sputum and blood.