Table 4– Pooled results of the increased risk (IR) in multiple respiratory health effects associated with 10 μg·m−3 increase in PM10, in subjects aged ≥35 years, by demographic characteristics and previous diseases, in six Italian cities from 2001 to 2005
n (%)IR# (95% CI)p-heterogeneityp-interaction+
Hospitalisations for all respiratory diseases
 Total100 690 (100)0.59 (0.10–1.08)0.718
 Age years
  35–6422 572 (22.4)0.05 (-0.86–0.97)0.984
  65–7426 093 (25.9)0.54 (-0.52–1.61)0.1110.513
  75–8434 492 (34.3)0.79 (0.06–1.52)0.8130.205
  ≥8517 533 (17.4)1.24 (0.25–2.23)0.5410.131
 Sex
  Males56 647 (56.3)0.50 (-0.08–1.09)0.310
  Females44 043 (43.7)0.79 (0.14–1.44)0.7400.473
 Previous ischaemic heart diseases§12 495 (12.4)1.59 (0.41–2.79)0.6970.074
Hospitalisations for COPD
 Total38 577 (100)0.67 (-0.02–1.35)0.580
 Age years
  35–645939 (15.4)0.20 (-1.24–1.66)0.748
  65–7411 640 (30.2)1.17 (-0.60–2.97)0.0190.230
  75–8415 092 (39.1)0.71 (-0.28–1.70)0.2350.537
  ≥855906 (15.3)0.05 (-1.49–1.61)0.6890.642
 Sex
  Males23 000 (59.6)0.93 (0.02–1.85)0.320
  Females15 577 (40.4)0.22 (-0.73–1.18)0.9640.371
 Previous ischaemic heart diseases§5466 (14.2)1.93 (0.33–3.55)0.3880.068
Hospitalisations for LRTI in COPD
 Total9886 (100)1.91 (0.06–3.79)0.655
 Age years
  35–641563 (15.8)0.78 (-3.41–5.15)0.827
  65–742569 (26.0)0.77 (-2.23–3.86)0.5010.883
  75–843726 (37.7)2.42 (-0.19–5.10)0.4320.504
  ≥852028 (20.5)3.78 (0.45–7.22)0.6600.243
 Sex
  Males6344 (64.2)2.46 (0.41–4.56)0.879
  Females3542 (35.8)1.27 (-1.36–3.96)0.2960.486
 Previous ischaemic heart diseases§1227 (12.4)4.89 (0.29–9.69)0.7550.192
Out-of-hospital respiratory deaths
 Total5490 (100)3.95 (1.53–6.43)0.344
 Age years
  35–64288 (5.2)-5.38 (-14.10–4.22)0.397
  65–74575 (10.5)4.00 (-2.98–11.48)0.7070.120
  75–841682 (30.6)5.07 (1.01–9.30)0.7040.049
  ≥852944 (53.6)4.82 (1.81–7.92)0.4680.047
 Sex
  Males2550 (46.4)1.98 (-1.32–5.40)0.098
  Females2940 (53.6)6.15 (3.06–9.33)0.3950.076
 Previous ischaemic heart diseases§476 (8.7)3.42 (-3.40–10.72)0.9430.820
  • IR are presented as %. Chronic obstructive pulmonary disease (COPD) was identified as principal diagnosis of COPD or respiratory failure with COPD as secondary diagnosis; lower respiratory tract infections (LRTI) (bronchitis and pneumonia) were identified as principal diagnosis with COPD as secondary diagnosis. PM10: particles with a 50% cut-off aerodynamic diameter of 10 μm. #: risk estimated at the best lag, hospitalisations for all respiratory diseases was lag 0–1 days, for COPD was lag 0 days, for LRTI in COPD was lag 0–3 days, and out-of-hospital mortality was lag 0–3 days; : p-value of heterogeneity test (null hypothesis is perfect homogeneity of city-specific results); +: p-value derived from the model with the interaction term (for each condition, the reference category is the group of subjects without the disease);§: discharge diagnosis in the period 29 days to 2 years before death, for International Classification of Diseases (ninth revision) codes 410–414. Bold type indicates the total effects, the statistically significant results within each variable, and the p-interaction values that identify an effect modification.