Table 1– Baseline characteristics (last measurements prior to surgery) of the entire patient population and of patients with or without major perioperative complications (POCs)
All patientsPOCNo POC
Subjects n1147107
Age years57 (48–67)54 (46–67)57 (48–67)
Female80 (70)5 (71)75 (70)
Type of PAH
 Idiopathic PAH57 (50)2 (28.6)51 (48)
 Familial PAH2 (1.8)1 (14)1 (1)
 Associated PAH55 (48)4 (57)55 (51)
NYHA class#
 NYHA I/II61 (54)1 (14)60 (56)
 NYHA III/IV49 (43)6 (86)43 (41)
6MWD
 6MWD <399 m46 (40)6 (86)40 (37)
 6MWD ≥399 m49(43)1 (14)48 (45)
Haemodynamics
 mRAP+ mmHg7 (3–10)7 (4–10)7 (3–10)
 mPAP§ mmHg45 (38–55)49 (38–58)45 (38–55)
 mPCWPƒ mmHg9 (6–12)9 (7–12)9 (6–12)
 Cardiac output## L·min−15.0 (4.2–5.9)5.1 (4.3–6.0)5 (4.2–5.9)
 Cardiac index¶¶ L·min−1·m-22.9 (2.5–3.5)2.9 (2.4–3.3)2.9 (2.5–3.5)
 PVR+ dyn·s·cm−5579 (368–804)616 (368–952)579 (368–804)
SvO2++ %66 (63–70)66 (62–69)66 (63–70)
Interval between last RHC and surgery months9 (4–26)6 (3–14)9 (4–26)
Type of surgery
 Abdominal45 (39)4 (57)41 (38)
  Gynaecology/urology22 (19)1 (14)21 (20)
 Trauma/orthopaedic21 (18)1 (14)20 (19)
 Other26 (22)1 (14)27 (25)
Location of surgery
 PH centre86 (75)4 (57)82 (77)
 Other28 (25)3 (43)25 (23)
Urgency
 Elective/intermediate101 (89)3 (43)98 (92)
 Emergency13 (11)4 (57)9 (8)
Monotherapy
 PDE5I17 (15)1(14)16 (15)
 ETRA23 (20)2 (28)21 (20)
 Prostanoid (nebulised)1 (1)0 (0)1 (1)
 Prostanoid (parenteral)11 (10)1 (14)10 (10)
Combination therapy
 ETRA + PDE5I22 (19)0 (0)22 (21)
 ETRA + PDE5I + prostanoid (nebulised)2 (2)1 (14)1 (1)
 ETRA + PDE5I + prostanoid (parenteral)6 (5)0 (0)6 (6)
 Prostanoid (nebulised) + PDE5I1 (1)0 (0)1 (1)
 Prostanoid (parenteral) + PDE5I9 (8)0 (0)9 (8)
 ETRA + prostanoid (nebulised)2 (2)0 (0)2 (2)
 ETRA + prostanoid (parenteral)1 (1)0 (0)1 (1)
  • Data are presented as median (interquartile range) or n (%), unless otherwise stated. PAH: pulmonary arterial hypertension; NYHA: New York Heart Association; 6MWD: 6-min walking distance; mRAP: mean right artery pressure; mPAP: mean pulmonary artery pressure; mPCWP: mean pulmonary capillary wedge pressure; PVR: pulmonary vascular resistance; SvO2: mixed venous oxygen saturation; RHC: right heart catheterisation; PH: pulmonary hypertension; PDE5I: phosphodiesterase-5-inhibitor; ETRA: endothelin receptor antagonist. #: missing, n=4; : missing, n=9; +: n=111; § : n=114; ƒ: n=106; ##: n=113; ¶¶: n=100; ++: n=87.