Table 2– Cox regression survival analysis to assess predictors of survival in pulmonary hypertension associated with chronic obstructive pulmonary disease
Univariate hazard ratio (95% CI)p-valueMultivariate hazard ratio (95% CI)p-value
Age years1.054 (1.024–1.086)<0.0011.040 (1.004–1.078)0.031
 Male1.602 (0.930–2.761)0.090
BMI kg·m−20.958 (0.922–0.996)0.029
 IV2.471 (1.421–4.296)0.0020.485 (0.249–0.943)0.033
ISWD m0.996 (0.993–0.999)0.011
 Mean RAP mmHg1.034 (0.980–1.091)0.225
 Mean PAP mmHg1.034 (1.011–1.057)0.003
 CI L·min·m−20.481 (0.331–0.699)<0.001
 PCWP mmHg0.945 (0.893–0.999)0.047
 PVR dyn·s·cm−51.001 (1.001–1.002)<0.001
SvO2 %0.918 (0.887–0.950)<0.0010.947 (0.910–0.986)0.008
HRCT scores
 Total emphysema1.047 (1.008–1.088)0.018
 Total fibrosis1.034 (0.956–1.119)0.407
Pulmonary function
 FEV1 % pred1.011 (1.001–1.025)0.006
 FVC % pred1.011 (1.001–1.022)0.039
DLCO % pred0.964 (0.946–0.982)<0.0010.975 (0.954–0.996)0.020
  • BMI: body mass index; WHO-FC: World Health Organization functional class; ISWD: incremental shuttle walking distance; RAP: right atrial pressure; PAP: pulmonary arterial pressure; CI: cardiac index; PCWP: pulmonary capillary wedge pressure; PVR: pulmonary vascular resistance; SvO2: mixed venous oxygen saturation; HRCT: high-resolution computed tomography; FEV1: forced expiratory volume in 1 s; % pred: % predicted; FVC: forced vital capacity; DLCO: diffusing capacity of the lung for carbon monoxide.