Table 2– Summary of studies examining the effect of smoking cessation on asthma outcomes
First author [ref.]ParticipantsFindings
Tonnesen [83]220 asthmatics undergoing a smoking cessation programme with NRT
At 4 months, 27 were abstainers, 33 reducers and 50 relapsers or continuing smokers
Improvements in the asthma-specific quality-of-life score, and reductions in self-reported day and night use of rescue β2-agonists, doses of ICS, daytime asthma symptoms and AHR were reported in the abstainers
For reducers, smaller improvements occurred for night use of rescue β2-agonists, doses of ICS and AHR
Piccillo [72]57 smokers with seasonal allergic rhinitis±asthma undergoing a smoking cessation programme with NRT±bupropion
At 12 months, 16 of the participants had quit smoking
A significant improvement in AHR to direct and indirect bronchoprovocation was observed after cessation in the quitters but not in the smoking cessation relapsers
Chaudhuri [59]32 asthmatic smokers given the option to quit or continue smoking 11 opted to continue smoking, whereas 10 out of 21 managed to quit smoking for up to 6 weeksAfter smoking cessation, quitters achieved considerable improvement in lung function and a fall in sputum neutrophil count compared with subjects who continued to smoke
  • NRT: nicotine replacement therapy; AHR: airway hyperresponsiveness; ICS: inhaled corticosteroids.