| A1AT deficiency | COPD | p-value | |
| Age years | 55±1.9 | 65±1.9 | 0.002 |
| Number of males | 22 (79) | 19 (86) | ns |
| Smoking history pack-years | 21±3.9 | 54±10.0 | 0.004 |
| FEV1 % pred | 49±5.9 | 72±5.8 | 0.004 |
| FEV1/FVC ratio | 0.41±0.04 | 0.49±0.04 | 0.031 |
| KCO % pred | 69±5.2 | 101±6.1 | 0.001 |
| HRCT evidence of emphysema | 22 (79) | 14 (64) | ns |
Data are presented as mean±sem or n (%). A1AT: alpha-1-antitrypsin; COPD: chronic obstructive pulmonary disease; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; KCO: carbon monoxide transfer coefficient; HRCT: high-resolution computed tomography; ns: nonsignificant