Table 3– Correlation coefficients between bronchoalveolar lavage growth factor and cytokine concentrations and outcomes
VFDsICU-free daysAPACHE IISOFAPa,O2/FI,O2 score
NRG-1-0.51 (p=0.015)-0.50 (p=0.015)0.19 (p=0.37)0.14 (p=0.91)-0.02 (p=0.91)
EGF0.31 (p=0.17)0.44 (p=0.038)-0.10 (p=0.66)0.16 (p=0.48)-0.13 (p=0.55)
IL-1β-0.29 (p=0.20)-0.17 (p=0.43)0.12 (p=0.59)0.01 (p=0.95)0.21 (p=0.34)
IL-6-0.34 (p=0.13)-0.22 (p=0.32)0.06 (p=0.79)0.26 (p=0.23)0.005 (p=0.98)
IL-8-0.12 (p=0.61)0.09 (p=0.69)0.28 (p=0.19)0.44 (p=0.04)0.11 (p=0.62)
TNF-α-0.26 (p=0.26)-0.15 (p=0.49)0.12 (p=0.60)0.09 (p=0.68)0.19 (p=0.40)

  • VFDs: ventilator-free days; ICU: intensive care unit; APACHE II: Acute Physiology and Chronic Health Evaluation II; SOFA: Sequential Organ Failure Assessment; Pa,O2: arterial oxygen tension; FI,O2: inspiratory oxygen fraction; NRG: neuregulin; EGF: epidermal growth factor; IL: interleukin; TNF: tumour necrosis factor.