Table 2– Haemodynamic, arterial blood gas profile and cardiopulmonary exercise testing parameters at rest and during exercise in 98 chronic obstructive pulmonary disease patients with or without pulmonary hypertension (PH)
VariableNon-PHPH
RestExerciseRestExercise
Subjects n7226
Mean Ppa mmHg18±337±829±4#48±7
sPpa mmHg28±455±1141±8#68±10
dPpa mmHg9±420±717±6#28±7
TPG mmHg10±320±618±6#31±7
Ppcw mmHg9±317±411±3#17±4
Pra mmHg5±39±37±3#11±3
PP mmHg18±535±924±9#39±9
TPR Wood units3.6±0.93.8±1.45.3±1.5#5.5±1.8
PVR Wood units2.0±0.92.1±1.03.3±1.4#3.7±1.6
PAC mL·mmHg−14.1±1.32.3±0.73.2±1.5#1.7±0.6
CO L·min−15.2±1.010.4±2.55.6±1.29.4±2.8
edPRV mmHg7±410±4#
fC beats·min−174±12108±1384±13#110±15
MPfC %69±969±10
Wc W74±2550±20
PaO2 kPa9.8±1.29.4±1.68.2±1.6#7.3±1.9
PaCO2 kPa5.3±0.65.6±0.85.7±0.8#6.2±1.1
SaO2 %96±294±492±5#85±9
CO/VO26.2±4.16.3±2.7
Maximum Borg 10 dyspnoea score9.3±1.49.2±1.7
fR breaths·min−120±435±723±6#33±8
Respiratory quotient1.0±0.10.9±0.1
VEmax L·min−146±1538±13
VE/MVV %90±23105±22
  • Data are presented as mean±sd, unless otherwise indicated. Ppa: pulmonary artery pressure; sPpa: systolic Ppa; dPpa: diastolic Ppa; TPG: transpulmonary pressure gradient; Ppcw: pulmonary capillary wedge pressure; Pra: right atrial pressure; PP; pulse pressure; TPR: total pulmonary vascular resistance; PVR: pulmonary vascular resistance; PAC: pulmonary arterial compliance; CO: cardiac output; edPRV: right ventricle end-diastolic pressure; fC: cardiac frequency; MPfC: maximum predicted fc; Wc: corrected workload; PaO2: arterial oxygen tension; PaCO2: arterial carbon dioxide tension; SaO2: arterial oxygen saturation; VO2: oxygen uptake; fR: respiratory frequency; VEmax: maximum minute ventilation; MVV: maximal voluntary ventilation. #: p<0.05, significantly different from non-PH for resting values; : p<0.05, significantly different from non-PH for exercise values. For all right heart catheterisation variables, except PVR in the non-PH group, there was a significant difference between rest and exercise values for haemodynamic variables. Workload obtained in cardiopulmonary exercise testing was similar to workload from right heart catheterisation.