Table 2– Inter-patient comparison of annual change in forced expiratory volume in 1 s (FEV1) and body mass index (BMI), and total days on i.v. antibiotics over a 5-yr period in females with cystic fibrosis aged <23 yrs and ≥23 yrs who were using oral contraceptives (OCs) (“exposed” cohort) and not using OCs (“not exposed” cohort)
Patients comparedSubjectsAnnual change in FEV1 % predp-value#SubjectsAnnual change in BMI kg·m−2p-value#SubjectsTotal i.v. antibiotic use over 5 yrs daysp-value#
All<0.005<0.05<0.05
 <23 yrs54-2.25 (-11.81–13.1)54-0.08 (-1.53–1.13)5156 (0–364)
 ≥23 yrs56-0.74 (-8.63–10.4)56-0.12 (-1.52–3.25)5728 (0–378)
<23 yrs0.0620.8690.468
 Exposed26-2.86 (-11.51–8.97)26-0.025 (-1.05–0.719)2556 (0–224)
 Not exposed27-1.52 (-11.82–13.11)28−0.16 (-1.54–1.13)2663 (0–364)
≥23 yrs0.7620.8760.86
 Exposed29-0.74 (-8.63–10.36)290.11 (-0.93–1.57)2928 (0–308)
 Not exposed27-0.74 (-7.98–3.14)270.17 (-1.52–3.25)2828 (0–378)
  • Data are presented as n or median (range), unless otherwise stated. % pred: % predicted. #: exposed versus not exposed to OCs.