Table 5– Diagnostic accuracy of serum mesothelin in patients with estimated glomerular filtration rate ≤59 mL·min−1 (chronic kidney disease stage ≥3), excluding those undiagnosed or with unconfirmed malignancy
Serum mesothelinMPMNot MPMTotal
≥1.5 nM72936
<1.5 nM12829
Total85765
Sensitivity %88.9 (51.8–99.7)
Specificity %49.1 (35.6–62.7)
PPV %21.6 (9.8–38.2)
NPV %96.6 (82.2–99.9)

  • Data are presented as n or % (95% CI). MPM: malignant pleural mesothelioma; PPV: positive predictive value; NPV: negative predictive value.