Table 1– Demographics of subjects
HealthySmokersACEiUCCCVA/EBCOPDBronchitisAsthmaILD
Female n (%)44 (27)6 (3)4 (0)34 (27)8 (7)9 (5)5 (2)9 (5)3 (1)
Age yrs55 (20–80)40 (23–55)64 (37–80)60 (46–80)64 (43–68)68 (59–80)65 (59–69)52 (22–77)54 (35–67)
BMI kg·m−226±623±428±327±434±823±428±431±530±3
FEV1 % pred99±1493±11102±1991±1096±1664±1663±3385±1287±10
FEV1/FVC80±581±580±576±680±656±1368±2174±687±10
Sputum eosinophils %0.41±0.60.4±0.11.3±1.20.51±0.50.53±0.70.73±0.50.41±0.70.22±0.60.46±0.65
Sputum neutrophils %49±2976±1675±2272±14.860±25.759±27.684.4±13.863.3±18.965.8±10.6
C2 μmol·L−18.7 (0.8)6.2 (0.6)2.6 (1.1)1.3 (0.5)1.45 (0.8)0.6 (0.5)1.3 (0.7)1.49 (1.1)0.05 (2.3)
C5 μmol·L−185.66 (1.2)26.3 (0.6)61.7 (2.1)35.8 (0.4)61 (0.9)24 (0.8)64 (0.5)15.7 (0.8)19 (0.5)
LCQ#11.4±3.98.2±3.712.9±3.614.1±5.811.5±5.314.2±7.1
VAS mm52±445±1240±630±923±553±19
Total coughs per 24 h18.6 (0.5)33 (0.6)128 (0.2)477 (0.3)321 (0.3)213 (0.3)106 (0.7)107 (0.3)274 (0.8)
  • Data are presented as median (interquartile range), mean±sd or geometric mean (log sd), unless otherwise stated. ACEi: angiotensin converting enzyme inhibitors; UCC: unexplained chronic cough; CVA: cough variant asthma; EB: eosinophilic bronchitis; COPD; chronic obstructive pulmonary disease; ILD: interstitial lung disease; BMI: body mass index; FEV1: forced expiratory volume in 1 s; % pred: % predicted; FVC: forced vital capacity; C2: concentration of capsaicin required to elicit two coughs; C5: concentration of capsaicin required to elicit five coughs; LCQ: Leicester Cough Questionnaire; VAS: Visual Analogue Score. #: the LCQ is a 19-item validated quality of life questionnaire for patients with chronic cough. It assesses three domains (physical, psychological and social); the total score range is 3 to 21 and a higher score indicates a better quality of life. : the VAS is a 100-mm score set at 0 and 100 by “no cough” and “worst cough ever”, respectively.