Table 1– Patient characteristics at baseline

	All patients	CV-			CV+
	All patients	All	Responders	Nonresponders	All	Nonresponders	Responders
Subjects	80	51	36	15	29	24	5
Demographics
Age yrs	63±9	63±10	63±9	62±10	63±9	62±9	70±5
Male	39 (49)	26 (51)	18 (50)	8 (53)	13 (45)	8 (33)	5 (100)
BMI kg·m⁻²	24.1±3.3	24.1±3.2	24.3±2.6	23.5±4.4	24.0±3.4	23.4±3.3	26.9±2.5
History of TLVR	7 (7)	5 (9)	3 (8)	2 (13)	2 (7)	0	2 (40)
Smoking status n
Former smoker	77	48	34	14	29	24	5
Current smoker	2	2	2	0	0	0	0
Never-smoker	1	1	0	1	0	0	0
Lung function
FEV₁ % pred	32±10	32±10	33±10	31±10	32±10	31±10	38±9
D_L,CO % pred	37± 15	37±16	39±17	32±12	37±14	37±15	36±13
RV % pred	239±62	237±53	237±50	237±61	242±76	255±76	181±43
TLC % pred	134±21	133±18	134±18	131±19	135±25	139±24	119±22
RV/TLC	0.66±0.1	0.66±0.1	0.66±0.09	0.65±0.1	0.67±0.11	0.68±0.11	0.62±0.13
Patient outcomes
6MWT^# m	317±111	327±117	324±108	335±140	298±97	299±102	291±84
SGRQ^¶ points	63±12	63±12	64±12	60±11	63±13	58±16	64±13
Emphysema characteristics
α₁-antitrypsin deficiency	3 (3)	3 (5)	2 (6)	1 (7)	0	0	0
Heterogeneity
Heterogeneity score	19±14	20±15	22±15	16±16	18±12	18±14	16±6
≤15% (nonheterogeneous)	36 (44)	20 (39)	14 (39)	6 (40)	16 (55)	12 (50)	4 (80)
Not determined	4 (5)	3 (6)	2 (6)	1 (6)	1 (3)	1 (4)	0
Target lobe
Right upper	35 (44)	15 (29)	8 (22)	7 (47)	20 (69)	18 (75)	2 (40)
Right middle	2 (3)	2 (4)	1 (3)	1 (7)	0	0	0
Right middle and right lower	1 (1)	1 (2)	0	1 (7)	0	0	0
Right lower	8 (10)	7 (14)	5 (14)	2 (13)	1 (4)	0	1 (20)
Left upper	17 (21)	12 (24)	10 (28)	2 (13)	5 (17)	5 (21)	0
Left lower	17 (21)	14 (27)	12 (33)	2 (13)	3 (10)	1 (4)	2 (40)
History of lung transplant, LVRS or BVR	7 (9)	5 (10)	2 (6)	3 (20)	2 (7)	2 (8)	0
Bullae	5 (6)	3 (6)	2 (6)	1 (7)	2 (7)	1 (4)	1 (20)

Data are presented as mean±sd or n (%), unless otherwise stated. CV-: collateral ventilation absent; CV+: collateral ventilation present; BMI: body mass index; TLVR: target lobe volume reduction; FEV₁: forced expiratory volume in 1 s; % pred: % predicted; D_L,CO: diffusing capacity of the lung for carbon monoxide; RV: residual volume; TLC: total lung capacity; 6MWT: 6-min walking test; SGRQ: St. George’s Respiratory Questionnaire; LVRS: lung volume reduction surgery; BVR: bronchoscopic volume reduction. ^#: all patients (n=76); CV-_all (n=49); CV-_responders (n=34); CV+_all (n=27); CV+_{nonresponders} (n=3). ^¶: all patients (n=58); CV-_all (n=37); CV-_responders (n=26); CV-_{nonresponders} (n=11); CV+_all (n=21); CV+_{nonresponders} (n=18); CV+_responders (n=3).