Table 1– Primary end-points used in clinical trials, 2004–2012
First author [ref.]FVCVCDL,COOxygenation6MWTSurvivalHospitalisationPFS
Noth [57]+++
Raghu [58]+
King [59]+
Richeldi [60]+
Noble [61]+
Zisman [62]+
Taniguchi [63]+
Daniels [64]+
King [65]+
Raghu [66]+++
King [67]+
Kubo [68]++
Demedts [69]++
Azuma [70]+
Raghu [71]+
  • FVC: forced vital capacity; VC: vital capacity; DL,CO: diffusing capacity of the lung for carbon monoxide; 6MWT: 6-min walk test; PFS: progression-free survival.