Table 5– Treatment outcomes of 121 multidrug-resistant tuberculosis (TB) cases enrolled in the meta-analysis
All treatmentsLNZ daily dose ≤600 mgLNZ daily dose >600 mgp-value
Patients treated with linezolid72 (59.5)49 (40.5)
XDR-TB25/71 (35.2)14/49 (28.6)0.45
Sputum smear conversion86/93 (92.5)54/59 (91.5)42/44 (95.5)0.43
Culture conversion100/107 (93.5)54/59 (91.5)46/48 (95.8)0.37
Period from start of anti-TB therapy to sputum smear conversion days43.5 (21–90)45.5 (28–91)92.5 (35–120)0.02
2-month culture conversion37/72 (51.4)18/42 (42.9)19/30 (63.3)0.09
Period from start of anti-TB therapy to culture conversion days61 (29–119)28 (20–45)60 (42–115)0.07
Definite treatment outcomes
 Cured98/121 (81.0)59/72 (81.9)39/49 (79.6)0.75
 Treatment completed1/121 (0.8)1/72 (1.4)
 Died17/121 (14.1)9/72 (12.5)8/49 (16.3)0.56
 Failed5/121 (4.1)3/72 (4.2)2/49 (4.1)0.98
  • Data are presented as n (%), n/N (%) or median (interquartile range), unless otherwise stated. LNZ: linezolid; XDR-TB: extensively drug-resistant TB.