Table 5– Clinical features of asthma patients who had infrequent and frequent exacerbations
Patients with infrequent# exacerbationsPatients with frequent exacerbations
Subjects2541
Age yrs51.7±2.855.0±1.7
Males/females*16/915/26
BMI* kg·m−228.1±1.332.1±1.2
GINA step 4/516/917/24
Smoking pack-yrs6.2±2.77.4±1.9
Post-BD FEV1 % pred85.8±4.478.2±3.3
Post-BD FEV1/FVC %67.0±2.567.9±1.7
Duration of disease yrs26.8±4.229.3±2.6
Sputum eosinophil count+ % geometric mean (95% CI)2.5 (1.1–5.4)1.8 (1.0–3.2)
Sputum neutrophil count %67.9±4.861.2±4.2
FeNO50§ ppb median (interquartile range)20.5 (13.7–44.5)20.9 (14.4–33.2)
ACQ score*1.7 (0.2)2.3 (0.2)
AQLQ score##5.2 (0.2)4.6 (0.2)
  • Data are presented as n or mean±se, unless otherwise stated. Groups compared using unpaired t-tests for normally distributed data and Fisher’s exact test for ratios. BMI: body mass index; GINA: Global Initiative for Asthma; BD: bronchodilator; FEV1: forced expiratory volume in 1 s; % pred: % predicted; FVC: forced vital capacity; FeNO50: exhaled nitric oxide fraction measured at a flow rate of 50 mL·s−1; ACQ: Asthma Control Questionnaire; AQLQ: Asthma Quality of Life Questionnaire. #: fewer than two exacerbations during the previous year; : two or more exacerbations during the previous year; +: unpaired t-test of log-transformed data for log-normally distributed data; §: Mann–Whitney U-test for nonparametric data; ƒ: on a scale of 0 (best) to 6 (worst); ##: on a scale of 1 (worst) to 7 (best). *: p<0.05 between groups.