Table 3– Clinical outcomes during hospitalisation and on day 30 of follow-up
Non-purulentPurulentp-value
Subjects3439
Primary end-point
 All patients
 Treatment failure on day 33 (9)4 (10)0.84
 Requirement for MV2
 Pulmonary infiltrates1
 Clinical deterioration31
 Death from any cause
 Patients with expectoration#
 Treatment failure on day 32 (8)3 (9)>0.99
 Requirement for MV1
 Pulmonary infiltrates1
 Clinical deterioration22
 Death from any cause
Secondary end-points
 In-hospital outcome
 Length of hospital stay days6.1±4.05.9±2.30.50
 In-hospital death
 Day 30 of follow-up
 All patients
 Treatment success on day 3031 (92)37 (94)0.86
 Complete clinical resolution
 Clinical improvement25 (74)18 (46)0.01
 Absence of clinical resolution6 (18)19 (49)0.053
 Patients with expectoration#2 (6)0 (0)0.12
 Treatment success on day 3022 (91)32 (95)>0.99
 Complete clinical resolution18 (75)16 (47)0.033
 Clinical improvement4 (17)16 (47)0.016
 Absence of clinical resolution2 (8)2 (6)>0.99
 New exacerbations7 (21)8 (20)0.99
 Exacerbation rate0.2±0.520.2±0.490.99
 Hospital re-admissions5 (14)4 (10)0.72
 Hospital re-admissions rate0.2±0.410.2±0.400.10
 Patients with antibiotic requirement4 (11)7 (17)0.59
 Patients with corticosteroids requirement7 (20)7 (17)0.47
 CRP0.96 (0.38–2.70)0.63 (0.38–2.70)0.91
 PTC0.03 (0.01–0.12)0.05 (0.01–0.19)0.31
 Death by any cause1 (3)2 (5)
  • Data are presented as n (%), mean±sd or median (interquartile range), unless otherwise stated. MV: mechanical ventilation; CRP: C-reactive protein; PTC: procalcitonin. #: 24 out of 34 patients in the non-purulent group and 34 out of 39 patients in the purulent group had expectoration and respiratory sample.