| Normoxia | Hypoxia | |||||
| Control | Curative | Preventive | Control | Curative | Preventive | |
| Pa,O2 | 86.6±8.1 | 80.7±11.4 | 82.6±16.1 | 88.6±12.2 | 95.1±7.8 | 93.5±14.1 |
| Pa,CO2 | 53.1±8.3 | 56.5±7.4 | 54.1±3.9 | 48.3±3.9 | 47.3±8.2 | 48.8±8.4 |
| PA–a,O2 | 7.6±5.9 | 12.5±10.0 | 14.1±15.8 | 10.8±12.8 | 7.4±9.3 | 7.5±13.0 |
| pH | 7.41±0.06 | 7.32±0.04* | 7.36±0.04* | 7.35±0.02 | 7.26±0.05# | 7.25±0.05# |
| [HCO3-] mmol·L−1 | 34.0±3.1 | 29.5±2.7* | 30.7±1.3* | 27.9±1.8 | 21.1±1.8# | 21.7±1.9# |
| Base Excess 103·μL−1 | 9.2±3.4 | 2.4±2.5* | 5.1±1.7* | 1.6±1.8 | -5.7±1.9# | -5.9±1.8# |
| Hct % | 44.6±5.4 | 42.6±3.2 | 42.8±2.3 | 68.9±9.5 | 61.2±3.6# | 62.3±4.4# |
| RBC 106 cells per μL−1 | 7.7±0.3 | 7.5±0.3 | 7.5±0.3 | 10.2±0.9 | 9.9±0.8 | 10.1±0.6 |
| MCV fL | 54.9±1.8 | 55.9±1.6 | 56.2±2.4 | 66.8±2.4 | 65.1±2.6 | 62.8±2.4# |
| Hb g·dL−1 | 14.4±0.5 | 13.9±0.7 | 14.2±0.5 | 22.5±2.4 | 21.3±1.2 | 21.0±1.1 |
| WBC cells 103 per μL−1 | 11.7±2.3 | 11.0±2.3 | 10.0±1.2 | 10.9±1.6 | 9.6±0.9 | 10.1±1.6 |
| Platelets 103 cells per μL−1 | 756±58 | 832±50 | 784±63 | 452±177 | 556±108 | 479±70 |
| MCHC g·dL−1 | 34.1±0.6 | 33.2±0.7 | 33.5±0.6 | 33.1±0.9 | 33.2±0.5 | 34.1±0.6 |
| Reticulocytes % | 0.23±0.05 | 0.24±0.06 | 0.26±0.02 | 0.51±0.05* | 0.37±0.15*¶ | 0.39±0.1*¶ |
Data are presented as mean±sd. Pa,O2: arterial oxygen tension; Pa,CO2: arterial carbon dioxide tension; PA–a,O2: alveolar–arterial oxygen tension difference; [HCO3-]: blood bicarbonate concentration; Hct: haematocrit; RBC: red blood cell; MCV: mean corpuscular volume; Hb: haemoglobin; WBC: white blood cell; MCHC: mean corpuscular haemoglobin concentration. *: significantly different from the normoxia control group, p<0.05; #: significantly different from the hypoxic control group; ¶: significantly different from normoxia, p<0.05. All measurements were performed in normoxia. Bold indicates significant difference from normoxia, main effect, p<0.05.