Table 2– Inflammatory mediators and cells for α1-antitrypsin deficiency (A1ATD) patients and disease severity-matched controls with usual chronic obstructive pulmonary disease (COPD)
A1ATDUsual COPD
IL-8 nM11.29 (1.80–20.46)3.72 (1.41–13.72)**
MPO mg·mL−10.78 (0.46–2.10)1.77 (1.12–3.53)*
LTB4 nM12.16 (3.85–37.84)6.10 (1.35–17.81)**
Absolute sputum neutrophil count 106·mL−12.6 (0.9–5.7)6.1 (4.3–9.8)**
Absolute sputum macrophage count 106·mL−10.6 (0.3–1.35)0.3 (0.1–0.7)
  • Data are presented as overall median (interquartile range). The overall median is calculated using the average mediator concentration or cell count from each of the nine visits for each subject in each patient group. IL: interleukin; MPO: myeloperoxidase; LTB4: leukotriene B4. *: p<0.05; **: p<0.01.