Table 1– Anthropometric characteristics and functional status of severe chronic obstructive pulmonary disease (COPD) patients and controls
Control subjectsNonwasted severe COPD patientsMuscle-wasted severe COPD patients
Subjects n101118
Age yrs65±967±563±11
BMI kg·m−228.2±4.428.5±4.618.9±2.6***,###
FFMI kg·m−222.5±2.522.7±2.415.9±1.7***,###
FEV1 % pred95±2245±19***32±14***,#
FVC % pred95±1478±18**55±12***,#
FEV1/FVC75±1144±11***42±11***
RV %110±3169±46**208±62***
TLC % pred113±18109±12116±17**
RV/TLC43±254±10**67±10***,##
DL,CO % pred106±1858±20***34±12***,##
KCO % pred97±2139±26***38±21***
Psub>a,O2 kPa12.6±1.79.6±1.8*9.7±0.9*
Pa,CO2 kPa4.9±0.55.8±0.7*5.8±1.1*
VO2,max % pred98±1377±18*29±7***,###
Wpeak % pred95±1566±18**23±11***,###
QMVC kg39.3±3.730.7±3.2***28.4±2.4***
  • Data are presented as mean±sd, unless otherwise stated. BMI: body mass index; FFMI: fat-free mass index; FEV1: forced expiratory volume in 1 s; % pred: % predicted; FVC: forced vital capacity; RV: residual volume; TLC: total lung capacity; DL,CO: diffusing capacity of the lung for carbon monoxide; KCO: transfer coefficient of the lung for carbon monoxide; Pa,O2: arterial oxygen tension; Pa,CO2: arterial carbon dioxide tension; VO2,max: maximal exercise oxygen uptake; Wpeak: peak work rate; QMVC: quadriceps isometric maximum voluntary contraction. *: p≤0.05; **: p≤0.01; ***: p≤0.001, between any of the groups of severe COPD patients and controls. #: p≤0.05; ##: p≤0.01; ###: p≤0.001, between nonwasted and wasted severe COPD patients.