Days | IL-8 | MPO | LTB_{4} | Neutrophil | Macrophage | |||||

A1ATD | COPD | A1ATD | COPD | A1ATD | COPD | A1ATD | COPD | A1ATD | COPD | |

1 | 31 | 83 | 339 | 80 | 18 | 66 | 53 | 26 | 78 | 32 |

3 | 4 | 7 | 38 | 6 | 4 | 4 | 32 | 5 | 49 | 14 |

5 | 4 | 6 | 26 | 9 | 5 | 4 | 31 | 4 | 38 | 10 |

Data are presented as the numbers required to provide an 80% chance of detecting a 50% decrease in mediators or cells at the 5% level of significance. Power calculations were performed for each mediator or cell using data from the first study visit for 1 day data. Power calculations were performed using data collected on the first 3 days (visit 1 to 3) or the first 5 days for 3 and 5 day data, respectively. IL: interleukin; MPO: myeloperoxidase; LTB

_{4}: leukotriene B_{4}.