Table 3– Intra-patient variability of sputum inflammatory mediators and cell counts in matched stable patients with usual chronic obstructive pulmonary disease (COPD) and α1-antitrypsin deficiency (A1ATD)
IL-8MPOLTB4Sputum neutrophilsSputum macrophages
A1ATD28.9 (14.5–74.0)36.0 (18.3–44.3)32.0 (20.8–53.7)69.4 (67.2–117.2)111.2 (85.6–154.5)
COPD45.1 (22.0–88.1)72.2** (42.8–85.7)45.5 (14.8–122.9)23.0* (18.6–33.3)71.4 (37.5–97.9)
  • Data are presented as coefficient of variant (CV) median % (interquartile range). The median intra-patient (within patient) CV is derived from individual patients mediator-specific CV, calculated using logged data from nine visits. IL: interleukin; MPO: myeloperoxidase; LTB4: leukotriene B4. *: p<0.05; **: p<0.01.