No exacerbations | ≥1 exacerbation | |||
Variable | Slope (95% CI) | p-value | Slope (95% CI) | p-value |
Longer duration of follow up yrs | -1.21 (-1.48– -0.95) | <0.0001 | -2.43 (-2.78– -2.08) | <0.0001 |
Increasing age yrs | -0.19 (-0.26– -0.13) | <0.0001 | -0.25 (-0.35– -0.16) | <0.0001 |
Earlier study entry calendar yr | -0.33 (-0.58– -0.08) | 0.010 | -0.92 (-1.24–0.60) | <0.0001 |
Lower baseline FEV1 % pred | -0.81 (-0.84– -0.78) | <0.0001 | -0.73 (-0.78– -0.69) | <0.0001 |
BMI | ||||
Normal weight | Ref. | Ref. | Ref. | Ref. |
Underweight | -3.56 (-4.85– -2.27) | <0.0001 | -8.00 (-8.73– -7.26) | <0.0001 |
Overweight | 3.81 (2.90–4.72) | <0.0001 | 4.21 (3.35–5.09) | <0.0001 |
BCC infection | -6.46 (-8.80– -4.12) | <0.0001 | -2.78 (-5.53– -0.08) | <0.0001 |
After adjusting for the other potential confounders, patients in the no exacerbations group with Burkholderia cepacia complex (BCC) infection have an annual rate of forced expiratory volume in 1 s (FEV1) decline that is 6.46% greater than the group without BCC infection. % pred: % predicted; BMI: body mass index; Ref.: reference.