Time point | Nicotine mouth spray^{#} | Placebo^{¶} | p-value^{+} | Risk ratio (95% CI)^{§} | Odds ratio (95% CI)^{§} |

Week 4 | 101 (31.8) | 35 (21.7) | 0.022 | 1.46 (1.05–2.04) | 1.68 (1.08–2.61) |

Week 6 | 83 (26.1) | 26 (16.1) | 0.014 | 1.62 (1.09–2.41) | 1.83 (1.13–2.99) |

Week 8 | 78 (24.5) | 23 (14.3) | 0.009 | 1.72 (1.12–2.63) | 1.95 (1.17–3.25) |

Week12 | 64 (20.1) | 21 (13.0) | 0.055 | 1.54 (0.98–2.43) | 1.68 (0.98–2.87) |

Week 16 | 57 (17.9) | 15 (9.3) | 0.013 | 1.92 (1.13–3.29) | 2.13 (1.16–3.89) |

Week 20 | 53 (16.7) | 11 (6.8) | 0.003 | 2.44 (1.31–4.54) | 2.73 (1.38–5.38) |

Week 24 | 50 (15.7) | 11 (6.8) | 0.006 | 2.30 (1.23–4.30) | 2.54 (1.29–5.04) |

Week 52 | 44 (13.8) | 9 (5.6) | 0.007 | 2.48 (1.24–4.94) | 2.71 (1.29–5.71) |

Values are presented as n (%), unless otherwise stated.

^{#}: n=318;^{ ¶}: n=161;^{+}: p-values were calculated using the Chi-squared test;^{§}: estimated risk ratios/odds ratios and corresponding 95% confidence intervals were calculated using Mantel–Haenszel statistics.