Table 3– Associations between mutations, patients' variables and clinical parameters
Variable#CharacteristicsWild-typeMutatedp-value
TP53+
 HistologyADC85 (65.9)48 (39.7)<0.0001
SCC/others44 (31.8)73 (57)
 pT (1)T139 (30.5)37 (30.6)0.9810
T276 (59.4)74 (61.2)
T38 (6.3)7 (5.8)
T45 (3.9)3 (2.5)
 pN (1)N089 (69.5)84 (69.4)0.3696
N130 (23.4)35 (28.9)
N22 (1.6)0
Nx7 (5.5)2 (1.7)
 Smoking status (1)§Current smoker77 (60.2)75 (62)0.8287
Former smoker44 (34.4)42 (34.7)
Never-smoker7 (5.5)4 (3.3)
 Asbestos exposure (2)None100 (78.7)91 (75.2)0.8007
Yes27 (21.3)30 (24.8)
KRASƒ
 HistologyADC93 (45.8)41 (89.1)<0.0001
SCC/others110 (54.2)5 (10.9)
 pT (1)T168 (33.7)9 (19.6)0.10
T2, T3, T4134 (66.3)37 (80.4)
 pN (1)N0140 (69.3)33 (71.7)0.60
N1, N2, Nx62 (30.7)13 (28.3)
 Smoking status (1)§Current smoker128 (63.4)24 (52.2)0.08
Former smoker64 (31.7)21 (45.7)
Never-smoker10 (5)1 (2.2)
 Asbestos exposureNone154 (76.2)36 (80)0.82
Yes48 (23.8)9 (20)
EGFR##
 SexMale92 (81.4)11 (64.7)0.35
Female21 (18.6)6 (35.3)
 Smoking status§Current smoker64 (56.6)8 (47.1)0.11
Former smoker43 (38.1)5 (29.4)
Never-smoker6 (5.3)4 (23.5)
 Sex/smoking statusOthers109 (96.5)13 (76.5)0.0067
Never-smoking females4 (3.5)4 (23.5)
 Pack-yrs (1)≤4061 (54.5)13 (76.5)0.15
>4051 (45.5)4 (23.5)
  • Data are presented as n (%), unless otherwise stated. pT: pathological tumour score; pN: pathological node score; ADC: adenocarcinoma; SCC: squamous cell carcinoma. #: values (1) and (2) are the number of patients with missing data for that variable; : Mantel–Haenszel test controlling for centre; +: wild-type n=129, mutated n=121; §: former smokers were patients who had quit smoking at least 2 yrs before interview and current smokers were patients who were smokers in the last 2 yrs before interview; ƒ: wild-type n=203, mutated n=46; ##: wild-type n=113, mutated n=17. p-values in bold are significant.